HIV TOPICS

Abbink TEM, Berkhout B, HIV-1 reverse transcription initiation: A potential target for novel antivirals?, Virus Res (2008), doi:10.1016/j.virusres.2007.12.009. Available online at www.sciencedirect.com.

Agris PF, Guenther R, Ingram PC, Basti MM, Stuart JW, Sochacka E, Malkiewicz A.Unconventional structure of tRNA(Lys)SUU anticodon explains tRNA's role in bacterial and mammalian ribosomal frameshifting and primer selection by HIV-1.RNA. 1997 Apr;3(4):420-8.

GENERAL, HIV AND BACTERIAL TOPICS

Agris PF, Guenther R, Ingram PC, Basti MM, Stuart JW, Sochacka E, Malkiewicz A. Unconventional structure of tRNA(Lys)SUU anticodon explains tRNA's role in bacterial and mammalian ribosomal frameshifting and primer selection by HIV-1. RNA. 1997 Apr;3(4):420-8.

GENERAL AND BACTERIAL TOPICS

Murphy FV 4th, Ramakrishnan V, Malkiewicz A, Agris PF. The role of modifications in codon discrimination by tRNA(Lys)uuu. Nat Struct Mol Biol. 2004 Dec;11(12):1186-91.

Phelps SS, Malkiewicz A, Agris PF, Joseph S. Modified nucleotides in tRNA(Lys) and tRNA(Val) are important for translocation. J Mol Biol. 2004 Apr 30;338(3):439-44.

Yarian C, Townsend H, Czestkowski W, Sochacka E, Malkiewicz AJ, Guenther R, Miskiewicz A, Agris PF. Accurate translation of the genetic code depends on tRNA modified nucleosides. J Biol Chem. 2002 May 10;277(19):16391-5.

GENERAL TOPICS

Ashraf SS, Guenther RH, Ansari G, Malkiewicz A, Sochacka E, Agris PF. Role of modified nucleosides of yeast tRNA(Phe) in ribosomal binding. Cell Biochem Biophys. 2000;33(3):241-52.

Stuart JW, Gdaniec Z, Guenther R, Marszalek M, Sochacka E, Malkiewicz A, Agris PF. Functional anticodon architecture of human tRNALys3 includes disruption of intraloop hydrogen bonding by the naturally occurring amino acid modification, t6A. Biochemistry. 2000 Nov 7;39(44):13396-404.

Yarian C, Marszalek M, Sochacka E, Malkiewicz A, Guenther R, Miskiewicz A, Agris PF. Modified nucleoside dependent Watson-Crick and wobble codon binding by tRNALysUUU species. Biochemistry. 2000 Nov 7;39(44):13390-5.

Sochacka E, Czerwinska G, Guenther R, Cain R, Agris PF, Malkiewicz A. Synthesis and properties of uniquely modified oligoribonucleotides: yeast tRNA(Phe) fragments with 6-methyluridine and 5,6-dimethyluridine at site-specific positions. Nucleosides Nucleotides Nucleic Acids. 2000 Mar;19(3):515-31.

Sengupta R, Vainauskas S, Yarian C, Sochacka E, Malkiewicz A, Guenther RH, Koshlap KM, Agris PF. Modified constructs of the tRNA TPsiC domain to probe substrate conformational requirements of m(1)A(58) and m(5)U(54) tRNA methyltransferases. Nucleic Acids Res. 2000 Mar 15;28(6):1374-80.

Agris PF, Guenther R, Sochacka E, Newman W, Czerwinska G, Liu G, Ye W, Malkiewicz A. Thermodynamic contribution of nucleoside modifications to yeast tRNA(Phe) anticodon stem loop analogs. Acta Biochim Pol. 1999;46(1):163-72.

Yarian CS, Basti MM, Cain RJ, Ansari G, Guenther RH, Sochacka E, Czerwinska G, Malkiewicz A, Agris PF. Structural and functional roles of the N1- and N3-protons of psi at tRNA's position 39. Nucleic Acids Res. 1999 Sep 1;27(17):3543-9.

Koshlap KM, Guenther R, Sochacka E, Malkiewicz A, Agris PF. A distinctive RNA fold: the solution structure of an analogue of the yeast tRNAPhe T Psi C domain. Biochemistry. 1999 Jul 6;38(27):8647-56.

Ashraf SS, Ansari G, Guenther R, Sochacka E, Malkiewicz A, Agris PF. The uridine in "U-turn": contributions to tRNA-ribosomal binding. RNA. 1999 Apr;5(4):503-11.

Ashraf SS, Sochacka E, Cain R, Guenther R, Malkiewicz A, Agris PF. Single atom modification (O-->S) of tRNA confers ribosome binding. RNA. 1999 Feb;5(2):188-94.

Guenther R, Forrest B, Newman W, Malkiewicz A, Agris PF. Modified RNAs as potential drug targets. Acta Biochim Pol. 1998;45(1):13-8.

Ashraf SS, Guenther R, Ye W, Lee Y, Malkiewicz A, Agris PF. Ribosomal binding of modified tRNA anticodons related to thermal stability. Nucleic Acids Symp Ser. 1997;(36):58-60.

Agris PF, Malkiewicz A, Guenther R, Basti M, Sengupta R, Stuart J. Importance of modified nucleosides to the structure and function of tRNAs. Nucleic Acids Symp Ser. 1995;(33):254-5.

Agris PF, Malkiewicz A, Kraszewski A, Everett K, Nawrot B, Sochacka E, Jankowska J, Guenther R. Site-selected introduction of modified purine and pyrimidine ribonucleosides into RNA by automated phosphoramidite chemistry. Biochimie. 1995; 77(1-2):125-34.

Dao V, Guenther R, Malkiewicz A, Nawrot B, Sochacka E, Kraszewski A, Jankowska J, Everett K, Agris PF. Ribosome binding of DNA analogs of tRNA requires base modifications and supports the "extended anticodon". Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2125-9.

Guenther RH, Bakal RS, Forrest B, Chen Y, Sengupta R, Nawrot B, Sochacka E, Jankowska J, Kraszewski A, Malkiewicz A, et al. Aminoacyl-tRNA synthetase and U54 methyltransferase recognize conformations of the yeast tRNA(Phe) anticodon and T stem/loop domain. Biochimie. 1994;76(12):1143-51.

Glasser AL, el Adlouni C, Keith G, Sochacka E, Malkiewicz A, Santos M, Tuite MF, Desgres. Presence and coding properties of 2'-O-methyl-5-carbamoylmethyluridine (ncm5Um) in the wobble position of the anticodon of tRNA(Leu) (U*AA) from brewer's yeast. FEBS Lett. 1992 Dec 21;314(3):381-5.

Malkiewicz AJ, Nawrot B, Sochacka E. The synthesis of tRNA sup (UGA) anticodons with the 2-thiouridine derivatives as the 'first letter'. Nucleic Acids Symp Ser. 1987;(18):97-100.

Sochacki M, Sochacka E, Malkiewicz A. Formation of the [b+41]+. ion in the mass spectra of 2-thiouridines. Biomed Mass Spectrom. 1980 Jun;7(6):257-8.

Hanna Sierzputowska-Gracz, Elzbieta Sochacka, Andrzej Malkiewicz, Kenneth Kuo, Charles W. Gehrke and Paul F. Agris. Chemistry and Structure of Modified Uridines in the Anticodon, Wobble Position of Transfer RNA Are Determined by Thiolation. Journal of American Chemical Society, 1987, 109, 7171-7177.

Paul F. Agris, Hanna Sierzputowska-Gracz, Wanda Smith, A. Malkiewicz, Alzbieta Sochacka and Barbara Nawrot. Thiolation of Uridine Carbon-2 Restricts the Motional Dynamics of the Transfer RNA Wobble Position Nucleoside. Journal of American Chemical Society 1992, 114, 2652-2656.